Article Type : Research Article
Authors : Franjic S
Keywords : Schizophrenia; Mental disorder; Mental health
Schizophrenia is a mental illness, a complex disorder of brain function that consists of a set of characteristic symptoms. Schizophrenia makes it difficult, distorted, or completely impossible for a sick person to distinguish between real and unreal experiences. Due to the wrong recognition of reality, logical thinking loses its usual determinants and moves on incomprehensible and illogical tracks.
Schizophrenia is the most common psychotic condition, characterized by hallucinations, delusions and thought disorders which lead to functional impairment [1]. It occurs in the absence of organic disease, alcohol or drug-related disorders and is not secondary to elevation or depression of mood. The aetiology of schizophrenia involves both biological and environmental factors. There is an increased likelihood of schizophrenia in those with a positive family history, and monozygotic twin studies show a 48% concordance rate. The dopamine hypothesis states that schizophrenia is secondary to over-activity of mesolimbic dopamine pathways in the brain. This is supported by conventional antipsychotics which work by blocking dopamine (D2) receptors, and by drugs that potentiate the pathway (e.g. anti-parkinsonian drugs and amphetamines) causing psychotic symptoms. Factors that interfere with early neurodevelopment such as obstetric complications, fetal injury and low birth weight lead to abnormalities expressed in the mature brain. Adverse life events and psychological stress increase the likelihood of developing schizophrenia. Expressed emotion is the theory that those with relatives that are ‘over’ involved or that make hostile or excessive critical comments are more likely to relapse. The stress–vulnerability model predicts that schizophrenia occurs due to environmental factors interacting with a genetic predisposition (or brain injury). Patients have different vulnerabilities and so different individuals need to be exposed to different levels of environmental factors to become psychotic.
Characteristics
Schizophrenia is a neurobiological disorder of the
brain categorized as a thought disorder with disturbances in thinking, feeling,
perceiving, and relating to others and the environment [2]. Schizophrenia is a
mixture of both positive and negative symptoms that are present for a
significant part of a 1-mo period but with continuous signs of disturbances
persisting for at least 6 mo. It is characterized by delusions, hallucinations,
disorganized speech and behavior, and other symptoms that cause social or
occupational dysfunction. Schizophrenia is considered one of the most disabling
of the major mental disorders, with an estimated 2.4 million or about 1.1
percent of Americans afflicted. It can occur at any age, but it tends to first
develop (or at least become evident) between adolescence and young adulthood.
Risk factors include maternal starvation and infections during fetal
development, complications during childbirth, childbirth that occurs in late
winter or early spring, and living in an urban environment. Theories of
causation include genetics, autoimmune factors, neuroanatomic changes, the
dopamine hypothesis (people with schizophrenia appear to have excessive dopamine
levels), and psychologic factors. There are several subtypes of schizophrenia,
including paranoid, disorganized, catatonic, undifferentiated, and residual.
Mental Disorder
Mental disorders are defined in diagnostic and
statistical manuals such as The Diagnostic and Statistical Manual of Mental
Disorders (DSM-5) and The International Statistical Classification of Diseases
and Related Health Problems (ICD-10), and include a broad range of syndromes,
which are generally characterized by some combination of abnormal thoughts,
emotions, behaviour, and/or cognitive impairments that have an effect on a
person’s ability to function and may also affect his or her relationships with
others [3]. The term ‘mental disorder’ is often used to refer to:
·
The major mental
illnesses (e.g. schizophrenia, bipolar affective disorders, depression,
generalized anxiety disorder, phobias, obsessive-compulsive disorders, eating
disorders, dementias, and delirium).
·
Conditions of
developmental origin (e.g. intellectual/learning disabilities, autism spectrum
conditions, and personality disorders).
·
Substance dependency
(e.g. alcohol or other mind-altering substances).
·
Symptoms associated with
physical illnesses (e.g. affective disorders in Parkinson’s and Huntington’s
diseases).
This broad range of mental disorders is common in
primary care, with prevalence rates reported in the range of 30–50%. Many of
these very varied disorders can be successfully treated or managed in a way
that reduces and minimizes their impact on a person’s life. Mental disorders
that are serious enough potentially to complicate the management of physical
health problems are also common. Accident and emergency (A&E) departments
frequently see patients who have self-harmed or have suffered injuries owing to
substance abuse. A person dependent on alcohol who is admitted for surgery may
develop withdrawal symptoms and delirium tremens some days after admission to
hospital because of forced abstinence from alcohol. Other examples are anxiety
and depression, both of which may arise on a general medical ward in the
context of a diagnosis of a life-limiting physical illness. People may also
present with symptoms that are not readily explained in which anxiety and
depression may be a significant factor.
Conditions
More than 50% of patients with schizophrenia have one
or more comorbid psychiatric or general medical conditions [4]. In a study
looking at hospital discharge records with a primary diagnosis of
schizophrenia, patients consistently showed higher proportions of all comorbid
psychiatric conditions examined and of some general medical conditions,
including acquired hypothyroidism, contact dermatitis and other eczema,
obesity, epilepsy, viral hepatitis, type 2 diabetes, essential hypertension,
and various chronic obstructive pulmonary diseases. Knowledge of the risks of
comorbid psychiatric and general medical conditions is critical both for
clinicians and for patients with schizophrenia. Closer attention to prevention,
early diagnosis, and treatment of comorbid conditions may decrease associated
morbidity and mortality and improve prognosis among patients with
schizophrenia. Schizophrenia symptoms include memory and attention problems,
hallucinations, disorganized thinking and behavior, and delusions. Psychotic
symptoms typically start in late adolescence and early adulthood. But
researchers believe that developmental abnormalities about which they do not
yet know also increase diabetes risk.
Psychosis
The term ‘psychosis’ is used when mental illness causes
the person to behave in such a bizarre and inappropriate manner that he or she
appears to have lost touch with reality [5]. The symptoms of psychotic
illnesses include the experience of delusions, hallucinations, disorganised
thoughts and speech, grossly disorganised behaviour as well as social
dysfunction. Psychotic illnesses comprise a large group of more specific
diagnoses, for example schizophrenia, persistent delusional disorder and
schizoaffective disorder. As these specific diagnoses are based on patterns of
symptom and behaviour in adults, the categories are not easily applicable to
children and young people. It can be difficult to be certain of the diagnosis
of a specific psychotic illness in adolescence. The picture often changes with
time and can be very mixed with overlap in symptom patterns. However, there is
often urgency to diagnose and begin effective treatment because of evidence
that the longer the untreated phase of illness, the worse the prognosis. For
this reason it is standard practice to refer to ‘early onset psychosis’ and to
leave the diagnosis undifferentiated for several years unless the criteria for
one of the specific psychotic disorders, such as schizophrenia, are absolutely
and exclusively fulfilled. As described previously, psychotic symptoms can
occur with mood disorders such as depressive disorder and bipolar disorder.
Personalities
The central characteristics of both schizoid and
schizotypal personalities include avoidance of others, severe deficiencies in
social skills, generalized withdrawal from life, and sometimes impairment in
perceptual and cognitive capacities [6]. Schizoid personality is a pattern of
aloof detachment from social interaction, with a restricted range of emotional
expression. These are people who don’t need people and are perfectly happy
being left to themselves (as opposed to avoidant personalities who actually
fear people). Schizotypal personality involves more serious disturbances of
thinking, more bizarre behavior, and possibly delusions. It is thought that
these two personality disorders really represent points on a continuum from
schizoid to schizotypal to outright schizophrenia, the latter characterized by
severe distortions of thought, perception, and action, including delusions and
hallucinations. In fact, schizoid and schizotypal personality disorders may
episodically decompensate into schizophrenic-like psychotic states, especially
under conditions of stress.
The flat, no engaged interpersonal style of the
schizoid crime victim may be mistaken for the affective blunting of PTSD. In
fact, a number of schizoid and schizotypal victims seem to react less strongly
than others to violence by virtue of their internal preoccupation with more
important idiosyncratic concerns. These subjects may seem detached and
disinterested during a law enforcement encounter, criminal justice proceeding,
or clinical interview, not because they’re ignoring or disrespecting the
interviewer, but because of their internal preoccupations or because human
interaction is of little interest to them to begin with. Any real distress may
be masked by their relatively nonresponsive style, so a careful clinical
history is still imperative. In most cases, their blank, far-away facial
expression and attitude will be quite noticeable.
Pet
Positron emission tomography (PET) was the first brain
scanning technique developed that allowed doctors and researchers to study
brain function rather than structure [7]. PET measures the emission of
positrons (anti-electrons) from the brain after a small amount of radioactive
isotope is injected into the subject’s bloodstream. The isotope used is a
short-lived radioactive tracer that decays by emitting a positron. It is
combined with a metabolically active molecule such as a sugar. Once injected, there
is a short waiting period while the sugar becomes concentrated in the tissues
being studied. The subject is placed in an imaging scanner, and the presence of
the isotope in the tissues is detected as it decays, emitting positrons. This,
therefore, shows the site of brain metabolism or function. PET has been used
extensively by doctors in efforts to understand which parts of the brain are
involved in many different neurologic illnesses, including seizures,
schizophrenia, and Parkinson’s disease. PET has also been used to answer other
interesting questions, such as which specific part or parts of the brain are
involved in certain activities, such as solving mathematic problems, word
puzzles, or cognitive tests. PET is an excellent and direct measure of brain
activity and can be used to determine brain function during various tasks or
during cognitive tests. The resolution is excellent, and allows a physician or
researcher to focus in on a very small region of the brain. If a dysfunction in
a particular region is suspected, that area can be examined minutely while the
subject is challenged with a task that is thought to be controlled in that
area. The glucose metabolism can then be measured and compared with other
areas.
Diagnosis
Formulating any diagnosis is a thoughtful process;
like any serious life illness, the ramifications can be life altering [8]. Not
only do the various psychotic disorders differ in their prognosis and in their
therapeutic management, but concluding the diagnosis of schizophrenia has serious
implications for the patient and the family. The diagnosis is a clinical
diagnosis, without the reliance on CT scans or blood tests to diagnose our
patients; we must use our analytical skills to reach an acceptable diagnosis.
There must be a systematic method of careful assessment and interviewing
skills, and collaboration and coordination of data with others when possible.
It is then when one can reach an objective diagnosis based on the information
and on clinical experience and the presence of the disruption in the patient’s
life. Since the length of time of the presence of psychotic material is a
differentiating factor, the relationship with the patient and, if possible,
family is crucial. The nurse–patient relationship creates a therapeutic alliance
that is critical to the success of this diagnostic process. A diagnosis of
schizophrenia obviously carries many implications; therefore, it is imperative
that one should always be careful to gather enough data over time to reach the
correct diagnosis. There are no laboratory tests yet that can confirm a
diagnosis of schizophrenia, so we rely on the assessment and the presence of a
constellation of symptoms and factors. Schizophrenia is often thought of as a
diagnosis of exclusion because the consequences of the diagnosis are severe and
can limit therapeutic options. There are other common conditions that include
psychosis as a prime symptom. DSM-5 (Diagnostic and Statistical Manual, fifth
edition) has organized these disorders across a spectrum, which is determined
by abnormalities in one or more domains. These include schizoaffective
disorder, delusional disorder, and brief psychotic disorder. In short,
schizoaffective disorder has features of both schizophrenia (thought) disorder
and an affective (mood) disorder. There are time frames for the duration and
relationship to the mood symptoms, as well as subtypes specified as bipolar
type or depressive type.
Misdiagnosis
Misdiagnosis usually
refers to a negligent failure to recognize the nature of the patient’s
condition, with harm resulting from the consequent failure to implement proper
measures of care [9]. A psychiatrist, for example, may be held liable for
negligently diagnosing a patient with a personality disorder as schizophrenic,
but only if the misdiagnosis affects treatment in a manner that leads to
subsequent harm. If, as a result of the diagnosis, the patient receives
neuroleptic medication and later develops TD, liability may well be imposed.
Liability may also be imposed if the patient is deemed likely to have improved
had the correct diagnosis been made. The mistaken diagnosis, however, must be
the result of the clinician’s negligence. Had the psychiatrist properly
inquired about the signs and symptoms of both schizophrenia and personality
disorder, only to have the patient lie about the presence of delusions, the
resulting mistake could not be attributed to the psychiatrist’s misfeasance.
Similarly, if after conducting an evaluation that conformed to the standard of
care, the psychiatrist was left with a difficult diagnostic dilemma and made a
reasonable judgment that turned out to be incorrect, liability should not
accrue.
The advances in
biological treatments of demonstrated efficacy have heightened the importance
of proper diagnosis. If the negligent failure to consider a diagnosis (e.g.,
the possibility that a psychotic illness represents bipolar disorder and not
schizophrenia) leads to a failure to use a potentially efficacious agent (e.g.,
a mood stabilizer), with prolonged suffering and repeated hospitalization as a
result, a good case for malpractice would seem apparent. If anything prevents
such cases from proliferating, it is probably (a) the condition of many of
these patients, who are chronically ill and socially impaired and thus unlikely
to initiate legal remedies; and (b) that still no absolute one-to-one
correlation exists between specific illness and specific treatment with certain
efficacy. Otherwise, misdiagnosis would seem to be a ripe area for future
litigation.
Hospitalization
There are several points to keep in mind when deciding
whether to hospitalize [10]. The first is the presence of a serious psychiatric
state along with suicidal threats. For diagnoses like schizophrenia, psychotic
depressions, or severe affective disorders, hospitalization may provide the
around-the-clock management that only a hospital can provide. A second
consideration for hospitalization is if the patient has overwhelming acute
problems and no social support. The second consideration is whether the person
lives in a home or social environment so destructive that they cannot manage in
it, and there are no other available refuges. A third consideration is to
monitor psychotropic medications when overdose risk is high. A fourth
consideration for hospitalization is when admissions are planned as a long-term
treatment plan. This could include conducting exposure treatment of
posttraumatic stress in a safe environment and planning a hospital stay when
the primary therapist is on vacation, among other, nonacute therapeutic
reasons. The fifth consideration is whenever suicide risk outweighs the risk of
inappropriate hospitalization. This consideration is especially important in
the hospitalization of chronically suicidal individuals, for whom unnecessary
hospitalization could be reinforcing suicidal behavior. There are alternatives
to hospitalization that provide necessary intensive treatment but without the
inpatient status. Partial hospitalization typically involves a day-treatment
program for several days or weeks and usually follows a period of inpatient
hospitalization. For example, a suicidal individual could spend several days in
inpatient care and then go home with the regimen of attending the partial
hospitalization program every day for 8 hours for 2 weeks. Basically the
patient eats an evening meal and sleeps at home, and spends the rest of the
time in treatment. Acute residential treatment involves 24-hour care that is
not typically held in a contained facility. They are generally viewed as a kind
of respite care and are less costly than inpatient admission. Observation or
holding beds allows extended assessment or 24-hour supervision while more
triaging options are entertained. Thus, there are more options than inpatient
hospitalization that are sometimes overlooked when a patient is deemed a danger
to go home alone. It is important for primary care providers to be aware of
local resources for comprehensive mental health treatment for suicidal
patients.
Conclusion
The severity of the
disorder varies from patient to patient: from people who can maintain a
satisfactory quality of life and work ability with their illness, to people who
may lose their ability to work due to the disorder and whose quality of life
can be significantly lower than before the disorder. Schizophrenia is a disease
that can be successfully controlled. It most often begins in adolescence,
although it can begin later. Symptoms may be unnoticeable at first, such as
difficulty concentrating and withdrawing from social relationships. Unfortunately,
a longer period of untreated symptoms causes greater and more permanent damage
to mental functions and makes it difficult for patients to recover. There is
evidence that a psychotic condition causes damage in brain cells that is
difficult to repair later. That is why it is important to start treatment as
early as possible. It is also important to prevent the onset of new episodes of
exacerbation with continuous treatment, as each new episode further damages the
patient and increases the risk of new episodes of exacerbation. Treatment
programs that combine biological, psychological and psychosocial methods of
treatment enable the stabilization of the patient's mental state, recovery of
functioning and prevention of new exacerbations.
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