Article Type : Case Report
Authors : Iken T, Remmal A, Nuiakjh J, Yazghi Martah L, Kournif H, Lamri H and Alaoui Rachidi S
Keywords : Adrenal myelolipoma; Cervical cancer; Tumour diseases; Retroperitoneal hemorrhage
Background: Adrenal myelolipoma is a rare,
benign, non-functioning tumor of the adrenal gland. Which is why it is often
asymptomatic, but it may be complicated by pain or retroperitoneal hemorrhage.
Medical imaging is key to the diagnosis by highlighting its fatty component,
non-present in other adrenal incidentalomas. Surgery is indicated when there is
a large or Complicated Myelolipoma. We report the case of a large symptomatic
adrenal myelolipoma discovered in a 50 year old woman.
Case Report: We describe a case of an 8cm
non-functional, and heterogenous right adrenal myelolipoma discovered on a
routine computed tomography (CT) scan evaluation for cervical cancer in a 50
years old woman.
Adrenal myelolipoma is a rare, benign, non-functioning
tumour of the adrenal gland. Which is often asymptomatic, but it may be
complicated by pain or retroperitoneal hemorrhage. Medical imaging is key to
the diagnosis by highlighting its fatty component, non-present in adrenal
incidentalomas. Surgery is indicated when there is a large or Complicated
Myelolipoma. We report the case of a large symptomatic adrenal myelolipoma
discovered in a 50 year old woman.
The patient was a 50 year-old married woman, G8P5,
diabetic, with a history of cervical cancer, was referred to our institution
for an adrenal mass found on a Ct scan performed to assess her cervical cancer.
Ct scan revealed a well-defined 8 cm Heterogenous mass of the right adrenal
gland. The patient exhibited no clinical signs of adrenal dysfunction: the
clinical evaluation was normal.
Once considered an autopsy curiosity, adrenal myelolipoma is now increasingly diagnosed with the frequent use of modern imaging methods. In a recent meta-analysis, fewer than 100 cases were reported [1]. The real incidence of adrenal myelolipoma is difficult to determine because of its rarity and its mostly asymptomatic character [2]. It is estimated to be between 0.08 and 0.2% in old autopsy series [3]. It is most often discovered in the fifth decade of life (extremes from 17 to 93 years) with a slight male predominance. Adrenal myelolipoma is most often unilateral, and is frequently associated with obesity, high blood pressure (HTA), endocrine disorders or various tumor diseases [3,4]. The origin of these tumors remains poorly understood. The metaplastic theory is the most widely accepted: the adrenal myelolipoma would derive from reticular cells of the adrenal cortical framework in response to an infection, to necrotic lesions of the adrenal gland or to chronic stress [4]. Adrenal myelolipoma is a non-secreting tumor that does not cause any adrenal hormonal dysfunction. It is most often asymptomatic [5]. It may manifest itself by non-specific symptoms consisting of nonspecific abdominal pain secondary to the mass effect in the case of large tumors, or intratumoral hemorrhagic and necrotic phenomena 2 '. High blood pressure may be observed in case of compression of a renal artery. Rarely, due to tumor rupture, patients may present with acute back pain, associated with a state of hypovolemic shock secondary to retroperitoneal hemorrhage. This is a serious complication that can be life-threatening and require emergency surgery [6]. Imaging studies are most often helpful in making the diagnosis and differentiating adrenal myelolipoma from other adrenal incidentalomas by demonstrating its fatty component 2". Ultrasound typically shows a markedly hyperechoic adrenal mass of solid nature. CT scan is the gold standard for the diagnosis. It usually shows a well-limited adrenal formation, which may be septate or contain fine calcifications that displace the healthy adrenal parenchyma. It allows above all to detect the fatty contingent of the tumor characterized by a negative density of -50 to -100 UH [7].
Figure
1: Axial
C+ abdominal stage in portal phase showing a
right adrenal mass with sharp and regular contours, hypodense (- 110 HU)
not enhancing after contrast injection.
Figure 2: Coronal C+ abdominal stage in portal phase showing a right adrenal mass with sharp and regular contours, hypodense (- 110 HU) not enhancing after contrast injection.
Figure
3:
Sagittal C+ abdominal stage in portal phase showing a right adrenal mass with
sharp and regular contours, hypodense (- 110 HU) not enhancing after contrast
injection.
This appearance may be confused with a
pheochromocytoma or a non-secreting adrenal carcinoma or even a renal
angiomyolipoma. In these situations, magnetic resonance imaging (MRI) can be
useful and allow a better tissue characterization of the components of the
adrenal myelolipoma by demonstrating a clear hypersignal on T1-weighted
sequences and a T2 signal attenuation for the fatty component as well as a
hyposignal in T1 and an intermediate signal in T2 for the hematopoietic
component. In case of persistent diagnostic doubt, particularly in patients
with a history of extrasensory neoplasia, or in bilateral forms, fine needle
aspiration guided by ultrasound or ct scan with cytological study is justified
and can sometimes avoid unnecessary surgery. Adrenalectomy is the primary
treatment and may be indicated in the following settings: painful forms,
complicated forms (hemorrhage, compression), doubt on a malignant component.
With the progress made in laparoscopic surgery, surgical excision is
increasingly recommended by this route [8]. Management of asymptomatic adrenal
myelolipoma, is controversial. They are most often simply monitored by imaging.
However, any increase in volume during follow-up will warrant surgical removal,
given the risk of haemorrhagic complications. A few authors systematically
indicate surgical removal from the outset, while others reserve this attitude
for large tumors [8-14]. Regular monitoring, based mainly on CT, is necessary
because of the possibility of development of lateral adrenal myelolipoma. The
prognosis after surgical treatment is good, with recurrence-free follow-ups of
up to 12 years (Figures 1-3).
Adrenal myelolipoma is a benign tumor, rare and often
asymptomatic of incidental discovery. Imaging usually allows the diagnosis to
be evoked. The complicated, sympathetic or voluminous nature of the adrenal
myelolipoma should indicate surgical removal with anatomopathological
confirmation. Otherwise, surveillance by imaging is recommended.